Measuring the extracellular acidification rate (ECAR), an indirect readout of the glycolytic rate, Lim et al. reported an attenuation of ECAR by the co-treatment with EGF stimulation together with gefitinib in an EGFR-overexpressing breast cancer cell line MDA-MB-468 [29]. The gene discussed is EGFR; the disease is breast carcinoma.