ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: When using a concentration of 0.25 μmol/L, which is below imatinib’s IC50 value (for CML-T1 IC50 is 0.69 ± 0.06 μmol/L and for K562 IC50 is 0.47 ± 0.04 μmol/L), lactate production was reduced in BCR-ABL-positive cell lines and concurrently, the production of glutamate increased, thus suggesting increased employment of the mitochondrial glucose pathway; when using a concentration above its IC50 value (2.5 μmol/L), no activation of TCA cycle was observed [45].