FGFR1 and breast carcinoma: In another study, FGFR1 inhibition by TKI258/dovitinib, a multikinase inhibitor (VEGFR, FGFR, PDGF, c-KIT, CSF-1R), significantly increased enzymatic activity of PKM2 in human myeloid leukemia cell line KG1, breast cancer cell line MDA-MB-134 and a lung cancer cell line NCI-H1299, all three of them overexpressing FGFR1 [61].