Second generation EGFR TKIs such as afatinib circumvented resistance elicited by T790M mutation providing improved PFS and Overall Survival (OS) [5, 8], but more encouraging are the third generation EGFR TKIs of which the most successful example is osimertinib, fully approved by the Food and Drug Administration (FDA) and European Comission for treating cancers that harbor the EGFR T790M mutation. Here, EGFR is linked to cancer.