ABL1 and leukemia: Oncogenic activation of the ABL1 kinase is induced as a consequence of the t(9;22)(q34;q11) chromosome translocation in Philadelphia-positive human leukemia, generating the new fusion gene BCR-ABL1, a cytoplasmic-target tyrosine kinase with constitutive activity, leading to abnormal cell proliferation and increased resistance to apoptosis [136].