RAF1 and lung carcinoma: The observation that RAS oncogene overexpressed with BRAFV600Erenders ERK signaling vemurafenib resistant and the essential participation of CRAF in lung cancers with mutations in KRAS leads to development of pan-RAF inhibitors, named LY3009120 and PLX8394, which do not activate MAPK signaling in tumors that harbor RAS mutations [92, 93].