ALK and neoplasm: Second generation ALK inhibitors, such as ceritinib, alectinib and brigatinib were developed mainly due to ALK+ tumor resistance, arising from ALK mutations C1156Y, L1196M, G1269A, F1174L, 1151Tins, L1152R, S1206Y, I1171T, G1202, D1203N and V1180L.