High level of the c-Met receptor was confirmed in human melanoma cells M14, M4Beu, A375 and Rel3, and the IC50 for c-Met inhibitor SU11274 was 4–5 μM [69].Contrary to the expected effect of HGF/c-Met inhibitor, in our experiments with the hypermetastatic and highly tumorigenic variant of human melanoma cell line A375 designated as Rel3 we have shown that SU11274 enriched for the melanoma-initiating cells in vivo. Here, HGF is linked to melanoma.