As our previous studies have shown that NEDD4 regulates EGFR endosomal trafficking for lysosomal degradation in NSCLC cells [13], and NEDD4 mediates EGF-promoted migration and invasion in gastric cancer cells [20], we wonder if NEDD4 plays the same role in mediating the EGFR migration signaling in NSCLC cells as in gastric cancer cells. The gene discussed is EGF; the disease is gastric cancer.