In a phase I/II trial of ASP8273 in Japanese patients with EGFR mutant NSCLC who had progressed on first line EGFR TKI, the ORR was 50%for all patients dosed with ≥100 mg with ORR of and 80% in T790 M positive patients. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.