JAK2 and Splenomegaly: Indeed, combined inhibition of JAK2, PI3K and mTOR in JAK2 V617F mutated cells causes reduction of both JAK2 and PI3K mediated STAT5 phosphorylation, impairment of the clonogenic potential of JAK2 V617F-mutated hematopoietic progenitors cells and reduced splenomegaly and myeloid cells infiltration in Jak2 V617F knock-in mice [54].