PDGFRA and gastrointestinal stromal tumor: Other RTK amplifications have also been reported in human cancers, including FGFR1 in lung and breast cancer [82, 83], FGFR3 in breast and bladder cancer [84, 85], ERBB4 in breast and gastric cancer [86, 87], FLT3 in colon cancer [88], KIT in melanoma and GIST [89, 90], and PDGFRA in GBM [91].