Last but certainly not least, fusion oncoproteins involving the TRKA, TRKB, and TRKC tyrosine kinases (which are encoded by NTRK1, NTRK2, and NTRK3, respectively) have been identified across nine tumor types, including sarcoma, melanoma, gliomas, thyroid, lung, colon, breast, head and neck cancers) [94]. Here, NTRK1 is linked to head and neck cancer.