ABCB1 and acute myeloid leukemia: So as to explore whether osimertinib could reverse ABCB1-mediated MDR in ex vivo, Chen et al. Collected bone marrow samples which highly expressed ABCB1 from patients diagnosed with AML and performed flow cytometric analysis to examine the effect of osimertinib on intracellular accumulation of Rhodamine 123 afterwards.