Pharmacologic inhibitors of EGFR (gefitinib and afatinib) resulted in 1.4–2.5-times lower miR-19b levels in 3 independent NSCLC cell lines harboring constitutive active EGFR mutations (Fig. 1c), but miR-19b levels were not affected by gefitinib in gefitinib-resistant PC9-ER cells, confirming the specificity of the TKI. This evidence concerns the gene EGFR and non-small cell lung carcinoma.