A few years ago, targeted NGS-based resequencing of the 25 most commonly mutated genes in myeloid leukemias/myelodysplasias revealed ASXL1, TET2, RUNX1, DNMT3A, EZH2 and TP53 mutations in 5 out 15 chronic phase CML patients at diagnosis [44]. The gene discussed is DNMT3A; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.