In treatment-naive ALK-positive NSCLC (PROFILE 1014), crizotinib significantly improved progression-free survival (PFS) (median, 10.9 months versus 7 months) and ORR as compared to standard first-line chemotherapy [32] indicating a clear and effective new strategy window for ALK-rearranged patients. Here, ALK is linked to non-small cell lung carcinoma.