CLOCK and prostate carcinoma: In particular, it is noteworthy that all the above-mentioned four shared genes belong to the positive loop of the circadian pathway (that is, the stimulatory component of the biological clock circuit; see Fig. 1) and that RORA is the most significant gene associated with all tumour types (except for prostate carcinoma, where it ranks second) and subtypes (see Tables 1 and 2).