To investigate the effects of pharmacological inhibition of ΙΚΚβ on osteoclast survival in the presence of breast cancer-derived factors, we generated mature osteoclasts and exposed these cells to the selective IKKβ inhibitors IKKβIII or IKKβV (10 μM) in the presence and absence of conditioned medium from human MDA-231 cells. This evidence concerns the gene IKBKB and breast carcinoma.