The DOCK7 rs1748195 SNP and rs1748195G-rs12563308T haplotype were associated with an increased risk of CAD (Recessive: OR = 1.79, 95% CI = 1.04-3.06, P = 0.017, Log-additive: OR = 1.27, 95% CI = 1.02-1.57, P = 0.014; OR = 1.37, 95% CI = 1.08-1.74, P = 0.009; respectively) and the severity to coronary atherosclerosis (OR = 1.46, 95% CI = 1.05-2.03, P = 0.023), whereas the ANGPTL3 rs12563308 SNP was associated with a decreased risk of CAD (Dominant: OR = 0.69, 95% CI = 0.45-0.94, P = 0.011; Log-additive: OR = 0.73, 95% CI = 0.49-0.89, P = 0.009). Here, ANGPTL3 is linked to coronary atherosclerosis.