Interestingly, analysis of the TCGA melanoma data revealed a significant (p = 0.03) inverse association of WNT3A gene expression with the five-year overall survival (OS) of melanoma patients when comparing the specimens with the highest (top 11%, n = 50) with lowest (bottom 11%, n = 50) gene expression (Fig. 1b). Here, WNT3A is linked to melanoma.