Interestingly, the agonist and the antagonist had opposing impacts on melanoma cell behavior in the neural crest compartment: Wnt3a enhanced, and PKF115–584 abrogated the spontaneous neural crest migration of SKMEL28 cells in vivo, which is in line with the effects of the neural crest-inducer BMP-2 and its physiological antagonist noggin [13]. This evidence concerns the gene NOG and melanoma.