The 6.25% frequency of BRCA1 frame shift mutations in our study is lower than reported frequencies in unselected triple negative breast cancers or in sporadic cases or in serous high-grade ovarian carcinomas without family history varying from 19 to 28%) (Gonzalez-Angulo et al. 2011; Rhiem et al. 2010) (Mafficini et al. 2016; Moschetta et al. 2016). The gene discussed is BRCA1; the disease is triple-negative breast carcinoma.