Since LFA-1 and ICAM-1 are also integral components of the HIV-1 virological synapse33,55, a supramolecular structure which mediates efficient viral transmission between infected and uninfected T-cells33, it is speculated that interactions of this adhesion molecules are not only important for infection with free virus particles but also for viral cell to cell transmission. This evidence concerns the gene ITGB2 and infection.