In this study, we used data acquired from The Cancer Genome Atlas (TCGA, http://cancergenome.nih.gov/) and Gene Expression Omnibus (GEO, https://www.ncbi.nlm.nih.gov/gds) whose gene expression microarray data can be mined to develop LncRNAs profiling36 to identify the predicted effects of lncRNAs on the relapse of ER-positive BC patients treated with tamoxifen. Here, ESR1 is linked to breast cancer.