Interestingly, lncRNA HNF1A-AS1, lncRNA CCND2-AS1, lncRNA CRNDE, lncRNA CASC2 were revealed that promotional effects on cell proliferation via activation of Wnt/β-catenin cascade in osteosarcoma, glioma, colorectal cancer and bladder cancer were documented, respectively75–78. This evidence concerns the gene CCND2 and central nervous system cancer.