To determine the therapeutic potential of targeting CXCR4 in this preclinical model of lung fibrosis, mice were treated starting at day 8 after bleomycin administration, at which point daily dosing commenced with either vehicle, AD-114-PA600-6H or AMD3100 (both at 10 mg/kg) until day 21. The gene discussed is CXCR4; the disease is pulmonary fibrosis.