Genome-wide association studies (GWASs) have explored many genes associated with serum uric acid levels or gout, for instance, SLC2A9, SLC2A12, SLC22A1212,13 for urate transporter, and ABCG2, SLC2A9, BCAS3, RFX3, KCNQ1, SLC22A12 and SLC17A1 for gout disease with individuals of Asian or European descent14–18. Here, RFX3 is linked to gout.