MAPT and Anxiety: In the elevated zero maze no effect of genotype was detected for time spent in the open and closed zones [one-way ANOVA, F (2, 55) = 0.5070, P = 0.6051; F (2, 55) = 0.9461, P = 0.3945], and number of entries into the open and closed zones [one-way ANOVA, F (2, 55) = 1.024, P = 0.3659; F (2, 55) = 0.4186, P = 0.6601], suggesting that Mapt deletion does not cause anxiety-like behavior (Fig. 1a–d).