MAPT and Anxiety: In line with what observed at six months of age (Fig. 1a), one-way ANOVA analysis of the elevated zero maze test found no significant main effect for genotype for entries and time spent into the zones [F (2, 55) = 0.2212; P = 0.8023, F (2, 55) = 0.3623, P = 0.6977; F (2, 55) = 0.66, P = 0.5299; F (2, 55) = 0.2471, P = 7480 Fig. 6a–d], confirming that Mapt deletion does not cause anxiety behavior alterations.