Because shed ALCAM-Iso2 can disrupt cell-cell adhesion at a physiologically relevant concentration and high ALCAM shedding is prognostic of poor patient outcome in bladder cancer19, we explored the phenotype of ALCAM-Iso1 and ALCAM-Iso2 in the bladder cancer cell line, UMUC-3. The gene discussed is ALCAM; the disease is urinary bladder carcinoma.