These results are in line with a recent study that demonstrated that MDH1 can recycle glycolytic NADH and support proliferation of cancer cells and activated lymphocytes (Hanse et al., 2017), two settings characterized by diminished mitochondrial function and high reliance on glycolysis (Vander Heiden et al., 2009, Pearce et al., 2013). This evidence concerns the gene MDH1 and cancer.