POLDIP2 and brain ischemia: The decreased permeability observed in Poldip2+/− mice after tMCAO was further confirmed by horseradish peroxidase extravasation (data not shown) as well as in an alternative cerebral ischemia model induced by temporary unilateral carotid artery ligation followed by 7.5% hypoxia induction (Additional file 4: Figure S3).