TP53 and gastrointestinal stromal tumor: Obviously, TP53 mutations are a rather late event in GIST progression as the percentage of TP53 mutated GISTs was higher in the study of Romeo et al. in a metastatic GIST cohort and in a study of Ryu et al. in a series of 125 localized GIST with 22% TP53 mutated tumors.