IL6 and chronic kidney disease: Although the relationship between CKD and frailty is not completely understood, dysfunction of various systems, including hemoglobin, Interleukin 6 (IL-6), insulin-like growth factor 1 (IGF-1), dehydroepiandrosterone S (DHEA-S), hemoglobuline A1c (Hb A1c), 25-hydroxy vitamin D, vitamin B12, and carotenoids in frailty suggests common pathological pathways for both disorders 1,6.