Among the genes that are overexpressed during DENV infection but underexpressed during ZIKV infection are the molecular chaperone HSPA5 which has been shown to interact directly with the dengue E protein in liver cells (Jindadamrongwech et al., 2004), other members of the translocation machinery (SEC61B) or the TRAP complex (SSR1, SSR2), and ATF4, an ER-stress induced gene that interacts with DDIT3 and TRIB3. Here, HSPA5 is linked to Zika virus infectious disease.