COX4I1 and cancer: Furthermore, SAP-MT group showed higher level of renal mitochondria proteins including COX IV (0.73 ± 0.06 vs. Free MT: 0.13 ± 0.06, p < .001), and TFAM expression (3.63 ± 0.29 vs. Free MT: 1.80 ± 0.56, p < .01) than those of IRI and free MT group (Figure 3(A–C)).