Interestingly, the transcriptional profiling of tumours with mutations in these different genes shows that they segregate into two clusters: a ‘pseudohypoxic’ cluster that includes tumours with VHL and SDHx mutations and an ‘activated tyrosine kinase’ cluster, originally containing tumours with RET and NF1(Dahia et al. 2005). The gene discussed is VHL; the disease is neoplasm.