It seems that the complement factor H gene, located on the long arm of the first autosomal chromosome (1q31.3 – OMIM *134370, Fig. 1,2), involved in the macular age related degeneration (OMIM #610698) and in the complement factor H deficiency (OMIM #609814), is the most appropriate candidate for genetic inheritance as the encoded protein, i.e. regulatory protein for complement activation of C3 fraction of complement, binds to adrenomedullin, a peptide that belongs to the calcitonin family, eliciting vasodilator effects on the choroid [12,13]. This evidence concerns the gene CFH and hyperinsulinemic hypoglycemia, familial, 4.