Indeed, the t(8;21)(q22.q22) translocation, which was frequently observed in acute myeloid leukemia, induces the formation of the chimerical protein RUNX1 (runt-related transcription factor 1, also called AML1 or CBFA2) -MTG8 (ETO, CBFA2T1) which mimics an oncogenic TF. The gene discussed is RUNX1; the disease is acute myeloid leukemia.