It is now well established that GD, B, and T lymphocyte-mediated autoimmunity are known to be directed against four well-known thyroid antigens: thyroglobulin (Tg), thyroid peroxidase (TPO), sodium-iodide symporter (NIS) and the thyrotropin receptor (TSH-R) [15, 16]. The gene discussed is TG; the disease is Autoimmunity.