When outside pollen season, an obvious decline tendency of IL-13+ILC2s was found in patients with pollen-allergic asthma (6.94 ± 3.16% vs. 4.17 ± 1.98%, P < 0.05) and in those with HDM-allergic asthma (1.89 ± 0.70% vs. 1.44 ± 0.55%, P < 0.05), respectively. The gene discussed is IL13; the disease is allergic asthma.