Autoantibodies targeting Dsg3 are found during the mucosal-dominant phase in pemphigus vulgaris (mPV) which is frequently followed by a mucocutaneous phase (mcPV) with additional epidermal blistering and characterized by the presence of both anti-Dsg3 and anti-Dsg1 antibodies. The gene discussed is DSG3; the disease is pemphigus vulgaris.