Interestingly, one recent study illustrated that neutrophilic myeloid-derived suppressor cells (MDSCs) are induced in vitro upon infection with various Candida species, which functionally inhibit T cell responses via Dectin-1/CARD9 signaling and subsequently suppress ROS generation, indicating that CARD9 seems to function as a negative modulator in fungal immune response (73). The gene discussed is CARD9; the disease is infection.