TLR3 and tuberculosis: In an in vivo model of TLR3-triggered events as depicted (Figure 7B), intravenous injection of Poly I:C resulted in a robust upregulation of IFN-α and IFN-β in lungs (Figure 7C) and spleens (Figure S3A in Supplementary Material) of these mice, while mice with established TB injected Poly I:C 12 h prior to sacrifice, manifested a fairly dampened IFN-α and IFN-β response.