A systematic examination of the immune response to malaria among Malian children with asymptomatic S. haematobium demonstrate significantly more memory B cell response to pooled malaria vaccine antigens [apical membrane antigen 1 (AMA1) and merozoite surface protein 1 (MSP1)] (14), altered cytokine patterns characterized by IL-4 and IL-10 TH2-enrichment as well as IL-6 and IFN-γ elevation (8), and suppressed T regulatory cells response (15), compared to age-matched children without underlying schistosomiasis. The gene discussed is IL4; the disease is malaria.