As such, there is a growing body of literature that strengthens the role of P2X7-IL-1β pathway in mood disorders including depression and bipolar disorder (Chrovian et al., 2014; Stokes et al., 2015; Bhattacharya and Biber, 2016; Bhattacharya and Drevets, 2017). Here, P2RX7 is linked to bipolar disorder.