It is noteworthy that, besides the neuroprotective ability demonstrated by the natriuretic peptide, in SHSY5Y proliferating neuroblastoma cells the effects induced by ANP on Wnt signaling caused the inhibition of proliferation, as demonstrated by the MI decrement recorded in cells treated with concentration ≥ 100 nM (Supplementary Figure S1), as well as by the lower levels of the cell growth regulator c-Myc vs untreated control (data not shown) similarly to what we have previously demonstrated for colorectal cancer cells (Serafino et al., 2012; Serafino and Pierimarchi, 2014). Here, NPPA is linked to colorectal cancer.