NPPA and Parkinson disease: Indeed, we show that, in both DA neuron-like models, ANP is able to positively affect the Wnt/β-catenin signaling, by inducing β-catenin stabilization and nuclear translocation, similarly and even more efficiently than the Wnt1a - used as positive control of Wnt signaling activation - and that, through this mechanism, it exerts neuroprotective effect when these two cellular systems were subjected to 6-OHDA insult for mimicking the neurodegeneration of PD.