Interestingly, while in colorectal cancer cells, where the Wnt/β-catenin pathway is constitutively activated, ANP acts by inhibiting the signaling (Serafino et al., 2012), in neuroblastoma cells, in which the pathway is basically not activated, as demonstrated by the localization of β-catenin almost exclusively at the cell membrane, the natriuretic peptide inhibits cell proliferation by functioning as a Wnt pathway activator. The gene discussed is NPPA; the disease is neuroblastoma.