Secondly, whilst there is a decrease in GluA2 mRNA and protein levels in the hippocampus following ischemia (Gorter et al., 1997; Noh et al., 2005; Dixon et al., 2009) as well as GluA2 internalization (Blanco-Suarez and Hanley, 2014), an concomitant increase in GluA1 was not reported (Pellegrini-Giampietro et al., 1992; Soundarapandian et al., 2005). The gene discussed is GRIA1; the disease is ischemia.