GSK3B and early-onset autosomal dominant Alzheimer disease: In fact, abnormal GSK3β activity has been linked to schizophrenia, bipolar disorder, autism spectrum disorders, as well as Alzheimer's disease in which hyperactivity is commonly reported (Emamian et al., 2004; Hur and Zhou, 2010; Eldar-Finkelman and Martinez, 2011; Beurel et al., 2015).