ALS-related RNA-binding proteins such as FUS, hnRNPA1, TIA1, and TDP-43 have been reported to undergo liquid-liquid phase separation through a mechanism that involves a prion-like domain (Molliex et al., 2015; Gopal et al., 2017; Mackenzie et al., 2017). The gene discussed is HNRNPA1; the disease is amyotrophic lateral sclerosis.