Moreover, the proportion of progressing patients with 6 selected high-risk clinicopathologic factors (No-HT, tissue visfatin > 50%, LN metastasis, tumor stage III/IV, age > 50 years, and tumor size ≥ 2 cm) increased with cumulative score, indicating that these selected high-risk clinicopathologic factors were highly associated with breast cancer progression. The gene discussed is NAMPT; the disease is breast carcinoma.