TNF-α ≥ 6 pg/mL and C-peptide ≥ 360 pg/mL both remained significant predictors of GERD in the confounder-adjusted final multivariate model with odds ratios [OR(95%CI)] of 2.06(1.15–3.70) and 2.08(1.20–3.61), respectively (Table 1). This evidence concerns the gene TNF and gastroesophageal reflux disease.