Defective CFTR ion channel function due to the most common mutation of CFTR, ΔF508 mutation, has been shown to underline the pathogenesis of some of the disease conditions in CF, such as obstructive lung disease5,6, pancreas exocrine deficiency7, CF-related diabetes8, abnormal gonad function, and infertility9–11. This evidence concerns the gene CFTR and cystic fibrosis.