Given the high levels of BPIFA1 seen in the ME, but the absence of spontaneous OM or lack of significantly increased susceptibility to ME infection by NTHi in our Bpifa1−/− mice, we investigated the contribution of the protein to OM disease progression by studying compound mutant Bpifa1−/−Evi1Jbo/+ mice. Here, BPIFA1 is linked to ocular melanoma.