Therapeutic blockade of IL-15 in obese mice with cholangitis resulted in attenuated histological damage, lower numbers of infiltrating neutrophils and CD8+ T cells and reduced levels of proinflammatory cytokines and chemokines including IL-13, IL-17, C-GSF, CCL2, CCL3 and CXCL10. Here, CXCL10 is linked to cholangitis.