Induction of thymic T-cell lymphomas/leukemias, which were more aggressive in ATM−l−/hTCL1Atg animals (median survival 221 days) than those induced by the single-hit genotypes (ATM−/−/GFP+, 500 days, p = 0.028; ATMfl/fl/hTCL1Atg, 416 days, p = 0.042, log-rank tests; Fig. 8e, Supplementary Figs. 18c,d), provided affirmation of a TCL1/ATM cooperation. This evidence concerns the gene TCL1A and leukemia.