As hyperglycemia-induced oxidative stress, glomerular cell apoptosis, and insufficient autophagy comprise the hallmark of diabetic alterations in the kidney, we evaluated the effects of cinacalcet on high glucose-induced oxidative stress and on apoptosis with relevance to the CaMKKβ-AMPK-eNOS signaling in cultured HGECs. This evidence concerns the gene CAMKK2 and Hyperglycemia.