NF90 bounds to the 3′untranslated regions (3'-UTRs) of cyclin E1 mRNA, depletion of NF90 delays cell-cycle progression, inhibits cell proliferation, reduces tumorigenic capacity, and sensitizes hepatocellular carcinoma to the CDK (cyclin-dependent kinase) inhibitor roscovitine18. The gene discussed is CCNE1; the disease is hepatocellular carcinoma.